What If you had the chance to start over, to do it all again? For Samantha Newly (Ms. Applegate), this fantasy becomes a reality after a hit-and-run accident leaves her in an eight-day coma. When she awakens in the hospital, she is surrounded by family and friends. The only problem is that she has no idea who they are - or who she is. In medical terms, Sam has retrograde amnesia, which allows her to fully function in the world but leaves her with no personal memories. Most people would deem this disorder a curse. But Sam may come to call it a miracle.

As she sets out to rediscover herself, Sam is forced to rely on the only people who can help her -- an eclectic bunch of friends and family. Although now strangers to Sam, it's not long before she begins to get an idea of who she was before the accident.